ABSTRACT
Skin sympathetic response [SSR] is an electrophysiological techniques and a central polysynaptic process. In mood disorders there are some changes in the cortex, hypothalamus activity, limbic system and basalganglia. Therefore, we compare the SSR changes in the patients with depression, mania and healthy persons. The patients with depression and mania were chosen based on DSM IV criterion by the psychiatrist. In cross-sectional analytic study, control group was selcted away healthy men and women. The SSR was written by physiograph. The stimulat electrod was fixed on the middle finger of the left hand and 5 sympathetic responses were recored for every sample. The mean of amplitude, duration and latency time were computed and compared among three groups. The mean of latency in control, mania and depressed groups were not statistically difference [p=.8]. There were no difference between mean of duration in latency time in three groups. The mean of amplitude were not significant in three groups. It seems hypothalamus has not direct effect balance of sympathy skin responses